Hyaluronidase is an enzyme utilized to break down hyaluronic acid-based dermal fillers. The time required for complete filler dissolution following hyaluronidase injection is variable. Several factors influence this process, including the type and amount of filler present, the concentration and volume of hyaluronidase used, the individual’s metabolism, and the location of the injection. Observable reduction in filler volume can often be seen within 24 to 48 hours; however, complete resolution may take several days to weeks.
The use of hyaluronidase offers the significant benefit of reversibility in cases of overfilling, asymmetry, nodule formation, Tyndall effect (bluish discoloration), or vascular compromise following filler injection. Prior to the availability of hyaluronidase, correction of these complications often required either waiting for the filler to naturally degrade or surgical intervention. Hyaluronidase has thus revolutionized the management of complications associated with hyaluronic acid fillers, offering a less invasive and more immediate corrective option.
